SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis
نویسندگان
چکیده
منابع مشابه
Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins
Chronic inflammation of the intestinal mucosa is characteristic of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Helminth parasites have developed immunomodulatory strategies that may impact the outcome of several inflammatory diseases. Therefore, we investigated whether Taenia crassiceps infection is able to decrease the inflammatory effects of dextran sulfate sod...
متن کاملGlutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice
Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...
متن کاملProcessed coffee alleviates DSS-induced colitis in mice
Background: Coffee is one of the most widely consumed beverages in the world and it has been demonstrated that it has important therapeutic activities not only because of its caffeine content but also owing to the presence of other biologically active small molecules such as chlorogenic acid, trigonelline and cyclopentadiones. However, chlorogenic acid is degraded into catechol, pyrogallol and ...
متن کاملCardamonin Ameliorates Dss-induced Colitis
The anti-inflammatory effect and potential mechanism of cardamonin in 1 DSS-induced colitis 2 3 Gaiyan Ren, Aning Sun, Chao Deng, Jingjing Zhang, Xiaojun Wu, Xiaohui 4 Wei1, Sridhar Mani2, Wei Dou1 and Zhengtao Wang1 5 6 1 Shanghai Key Laboratory of Complex Prescription and MOE Key Laboratory for 7 Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai 8 University ...
متن کاملAlternatively activated macrophages in infection and autoimmunity.
Macrophages are innate immune cells that play an important role in activation of the immune response and wound healing. Pathogens that require T helper-type 2 (Th2) responses for effective clearance, such as parasitic worms, are strong inducers of alternatively activated or M2 macrophages. However, infections such as bacteria and viruses that require Th1-type responses may induce M2 as a strate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2011
ISSN: 0741-5400
DOI: 10.1189/jlb.0311124